Sclerodermatous Graft-vs-Host Disease

Imatinib as a potential treatment for sclerodermatous chronic graft-vs-host disease.

Juan A. Moreno-Romero, MD; Francesc Fernández-Avilés, MD; Enric Carreras, MD; Montserrat Rovira, MD; Carmen Martı́nez, MD; José M. Mascaró Jr, MD; Department of Dermatology (Drs Moreno-Romero and Mascaró) and Bone Marrow Transplant Unit, Department of Hematology (Drs Fernández-Avilés, Carreras, Rovira, and Martı́nez), Hospital Clı́nic, University of Barcelona, and Department of Dermatology, Hospit...

Sclerodermatous graft-vs-host disease: clinical and pathological study of 17 patients.

OBJECTIVE To collect and review all cases of sclerodermatous chronic graft-vs-host disease from January 1, 1982, through December 31, 2000. SETTING University hospital in Madrid, Spain. PATIENTS During the study period, 493 allogenic bone marrow transplantations were performed. Sclerotic lesions developed in 17 patients. RESULTS Sclerotic lesions appeared after a mean of 529 days. Previou...

Etretinate therapy for refractory sclerodermatous chronic graft-versus-host disease.

Chronic graft-versus-host disease (GVHD) is the most common late complication of allogeneic bone marrow transplantation (BMT). The sclerodermatous form of the disease is often refractory to standard treatment modalities. Based on reports of response to etretinate, a synthetic retinoid, among patients with scleroderma, we have added etretinate to the treatment regimen of 32 patients with refract...

Imatinib for sclerodermatous graft-versus-host disease in lung transplantation.

Imatinib has been proposed as a treatment for sclerodermatous chronic graft-versus-host disease (GVHD) due to its antifibrotic activity. Because imatinib has a potentially adverse effect on wound healing, the safety of its perioperative use in lung transplantation is unknown. Herein, we present a patient who underwent bilateral living-donor lobar lung transplantation for pulmonary complications ...

Sclerodermatous Graft-versus-Host Disease Arsenic Trioxide Prevents Murine